Nucleolar Reorganization Upon Site-Specific Double-Strand Break Induction
نویسندگان
چکیده
منابع مشابه
Double strand break repair.
DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...
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The integrity of genomic DNA is crucial for its function. And yet, DNA in living cells is inherently unstable. It is subject to mechanical stress and to many types of chemical modification that may lead to breaks in one or both strands of the double helix. Within the cell, reactive oxygen species generated by normal respiratory metabolism can cause double-strand breaks, as can stalled DNA repli...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2016
ISSN: 0022-1554,1551-5044
DOI: 10.1369/0022155416668505